- Products - Capsule Chewable Cream Dispersible tablet Injection Oral Gel Paediatric Drop Pellets Powder For Suspension Suspension Syrup Tablet   Search Product   Advanced Search Category : Formulations Sub Category : Proton Pump Inhibitor Theraputic Group : Antiulcerants Generic Group : Omeprazole Name : Anasec® Title : Absense of Excessive Acid Secretion; Box containing 8 blister strips of 6 capsules each. Type : Capsule Composition : Anasec® capsule: Each capsule contains 20 mg of Omeprazole BP as enteric coated granules.   Description : Omeprazole is a specific inhibitor of the gastric proton pump (H+/K+ -ATPase) in the parietal cell. There it produces dose dependent inhibition of acid secretion by binding to the enzyme and effectively reduces gastric acid secretion. After oral administration the onset of the antisecretory effect of Omeprazole occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When the drug is discontinued, secretory activity returns gradually over 2 to 5 days.   Mode Of Action : Omeprazole, a racemic mixture of two active enantiomers, reduces gastric acid secretion through a highly targeted mechanism of action. It is a specific inhibitor of the acid pump in the parietal cell. It is rapid acting and provides control through reversible inhibition of gastric acid secretion with once daily dosing. Omeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the intracellular canaliculi within the parietal cell, where it inhibits the enzyme H+/K+-ATPase, the acid pump. This effect on the final step of the gastric acid formation process is dose-dependent and provides for highly effective inhibition of both basal acid secretion and stimulated acid secretion, irrespective of the stimulus.   Indication : Omeprazole capsules are indicated for the treatment of: reflux esophagitis duodenal ulcer gastric ulcer NSAID-associated gastric and duodenal ulcers or erosions Acid related dyspepsia Zollinger-Ellison syndrome. In the treatment of peptic ulceration, the eradication of H.pylori, as the causative organism, must be a high priority. Accordingly, Omeprazole should be used as part of combination therapy for the eradication of H.pylori. Maintenance- Omeprazole capsules are indicated for maintenance treatment of: reflux esophagitis duodenal ulcer gastric ulcer Zollinger-Ellison syndrome.   Dose And Administration General Dose : Duodenal ulcer: 20 mg once daily for 4 weeks. In severe cases, 40 mg once daily for 4 weeks. Gastric ulcer: 20 mg once daily for 8 weeks. In severe cases, 40 mg once daily for 8 weeks. Erosive Reflux Oesophagitis: 20 mg once daily for 4 weeks. For those not fully healed, to be continued for 4 more weeks. Refractory Reflux esophagitis: 40 mg once daily for 8 weeks. Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed; 40 mg once daily has been given for 8 weeks in gastro-oesophageal reflux disease refractory to other treatment; maintenance 20 mg once daily. Acid reflux disease (long-term management), 10 mg daily increasing to 20 mg once daily if symptoms return. Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks according to response. Zollinger-Ellison Syndrome: 60 mg once daily, adjusted individually and continued as long as necessary. Most patients will be effectively controlled with 20-120 mg daily. Dosage above 80 mg should be divided and given twice daily.   Side Effect : Central and peripheral nervous system: Headache. Gastrointestinal: Diarrhea, constipation, abdominal pain, nausea/vomiting and flatulence.   Precaution : In the presence of any alarm symptom (e.g. significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melena) and when gastric ulcer is suspected or present, the possibility of malignancy should be excluded as treatment may alleviate symptoms and delay diagnosis.   Pregnancy And Lactation : Pregnancy: Results from three prospective epidemiological studies indicate no adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child. So Omeprazole can be used during pregnancy. Nursing mother: Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used.   Over Dose : Nausea, vomiting, dizziness, abdominal pain, diarrhoea and headache have been reported from overdose with Omeprazole. Also apathy, depression and confusion have been described in single cases. The symptoms described in connection to Omeprazole overdose have been transient, and no serious outcome due to Omeprazole has been reported. The rate of elimination was unchanged (first order kinetics) with increased doses and no specific treatment has been needed.   Contraindication : Adjustment is not required. Patients with severe liver disease should not require more than 20 mg Omeprazole daily. Omeprazole capsule is contraindicated in patients with known hypersensitivity to any component of the formulation.   Drug Interaction : Omeprazole can prolong the elimination of drugs that are metabolized by oxidation in the liver such as Diazepam, Warfarin and Phenytoin. Drugs that are metabolized by the cytochrome P-450 system such as cyclosporin, disulfiram, and benzodiazepines have been reported to show interactions with Omeprazole. Normal subjects did not show any interaction with theophylline and propranolol.   Pharmaceutical Precaution : Store in a cool and dry place, away from light.   Price : 144.96 RetailPrice : 192.00   All contents © copyright 2005, NOVO Healthcare and Pharma Ltd. All rights reserved.