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| Category : |
Formulations |
| Sub Category : |
Cardiovascular drug |
| Theraputic Group : |
Cardiovascular (Antihypertensives) |
| Generic Group : |
Ramipril |
| Name : |
Aceon® 2.5 tablet |
| Title : |
Box contains 3 blister strips of 10 film coated tablets each. |
| Type : |
Tablet |
| Description : |
| Aceon® (Ramipril) is an angiotensin converting enzyme (ACE) inhibitor, which after hydrolysis to ramiprilat, blocks the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. So, inhibition of ACE by Ramipril results in decreased plasma angiotensin II, which leads to the decreased vasopressor activity and decreased aldosterone secretion. Thus Ramipril exerts its antihypertensive activity. It is also effective in the management of heart failure and reduction of the risk of stroke, myocardial infarction and death from cardiovascular events. It is long acting and well tolerated, so, can be used in long term therapy. |
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| Indication : |
| Aceon® is indicated in the following cases:
Mild to severe hypertension
Congestive heart failure
To reduce the risk of stroke, myocardial infarction and death from cardiovascular events, and in patients with a history of cardiovascular disease. |
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| Dose And Administration |
| General Dose : |
| Hypertension: For the management of hypertension initial dose of Aceon® is 1.25 mg daily, it can be increased with an interval of 1-2 weeks; usual dosage range is 2.5-5 mg daily up to a maximum of 10 mg daily.
Congestive heart failure: In this case initial dose of Aceon® is 1.25 mg once daily under supervision; dosage can be increased at intervals of 1-2 weeks; maximum of 10 mg daily can be taken and if necessary in 2 divided doses.
For prophylaxis and after myocardial infarction (3-10 days after infarction): Initial dose of Aceon® is 2.5 mg twice daily; can be increased to 5 mg twice daily after 2 days; 2.5 mg to 5 mg twice daily for maintenance.
Dosage in renal impairment: For patients with hypertension and renal impairment the recommended initial dose is 1.25 mg Aceon® once daily. Subsequent dosage should be titrated according to individual tolerance and blood pressure response, up to a maximum of 5 mg daily. For patients with heart failure and renal impairment, the recommended dose is 1.25 mg once daily. The dose may be increased to 1.25 mg twice daily and up to a maximum dose of 2.5 mg twice daily depending upon clinical response and tolerability. |
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| Side Effect : |
| Ramipril is generally well tolerated. Dizziness, headache, fatigue and asthenia are commonly reported side effects. Other side effects occurring less frequently include symptomatic hypotension, cough, nausea, vomiting, diarrhea, rash, urticaria, oliguria, anxiety, amnesia etc.
Angioneurotic edema, anaphylactic reactions and hyperkalemia have also been reported rarely. |
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| Precaution : |
| Ramipril should be used with caution in patients with impaired renal function, hyperkalaemia, hypotension, and impaired hepatic function. |
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| Pregnancy And Lactation : |
| Pregnancy and lactation: Insufficient data is available for the use of Ramipril in pregnant and lactating mothers. Therefore, the use of Ramipril in pregnancy and lactation is not advisable.
Children: No information is yet available in the use of Ramipril in children. |
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| Contraindication : |
| Ramipril is contraindicated in patients who are hypersensitive to any component of this product and in patients with a history of angio-edema related to previous treatment with ACE inhibitor. |
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| Drug Interaction : |
| Concomitant administration with diuretics may lead to serious hypotension, and in addition to dangerous hyperkalaemia may occur with potassium sparing diuretics. Concomitant therapy with Lithium may increase the serum Lithium concentration. NSAIDs may reduce the antihypertensive effect of Ramipril and cause deterioration of renal function. |
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| Price : |
0.00 |
| Retail Price : |
0.00 |
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